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8 August 2017

posted Aug 8, 2017, 4:37 AM by Beck Lockwood

Top speakers lined up for NHS Health and Care Innovation Expo 2017

When: 11-12 September
Where: Manchester Central Convention Complex

NHS England Chief Executive Simon Stevens and Secretary of State for Health, Jeremy Hunt top the line-up of leading national speakers at this year’s Health and Care Innovation Expo 2017 – the most significant health and social care event of the year.

Delegates will have the chance to hear the latest on the progress of NHS England’s Five Year Forward View, which is leading the transformation of patient services in key areas such as cancer care, mental health and emergency and urgent care.

Click here for more information 


8 August 2017

posted Aug 8, 2017, 4:29 AM by Beck Lockwood

Yorkshire & Humber Genomic Medicine Centre Conference: Improving Patient Care & Outcomes

When: 27 September 2017
Where: The Studio, Leeds Riverside West

Genomic medicine is bringing the benefits of Personalised Medicine to patients in the NHS.  This is a free educational event for all healthcare professionals who want to explore  the impact of genomics  on patient care, diagnosis and treatment.

Come and hear about the exciting work and developments that are happening in our region.


Click here for more information and to book a place.

21 July 2017

posted Jul 21, 2017, 12:11 AM by Beck Lockwood   [ updated Jul 21, 2017, 2:35 AM ]

Testing for Raynaud's in Leeds

A mobile clinic to test people for signs of Raynaud’s, was held in Leeds last month.

Set up on Briggate between 26 June and 2 July, the clinic was set up by the national charity Scleroderma and Raynaud’s UK (SRUK), and run by Francesco Del Galdo, who leads the NIHR DEC Leeds Scleroderma Diagnostics programme.

Passers-by were able to drop into the clinic and have a quick, non-invasive test for Raynaud's. Called a caplilaroscopy, the test involves placing a finger under a strong microscope which shows the blood vessels under the skin. Clinicians looked at the shape and size of these blood vessel capillaries to determine if they have Raynaud's and whether they are at risk of developing scleroderma.

People who showed signs of Raynaud's or an underlying condition received further medical information, and a referral letter from Dr. Del Galdo to hand to their GP – this letter will enable them to attend the Leeds Raynaud's clinic for further testing.

Everyone who visited the clinic got to take away a photo of their capillaroscopy, and the results from their test, as well as information about Raynaud's and the work of the charity.

Dr Francesco Del Galdo, from the University of Leeds Institute of Rheumatic and Musculoskeletal Medicine and consultant rheumatologist at Leeds Teaching Hospitals NHS Trust, said: “This pilot testing programme in Leeds is critical in helping to raise awareness of the need for greater investment in to research for Raynaud's and Scleroderma, and we're hoping the data we gather could help us develop better diagnostic tests and treatments, saving time to the patients and money to the NHS."

The data gathered from the clinic will also be used in a research study being undertaken by Dr. Francesco Del Galdo to give us better information about the number of people affected by Scleroderma and Raynaud's in the UK. This will include using the data to feed the health economic model built with NIHR DEC Leeds to evaluate Raynaud’s testing within the Raynaud’s patient pathway. This is the first research project looking at providing evidence-based data on a mass scale and will be pivotal in helping SRUK create change for people affected by the conditions.

21 July 2017

posted Jul 21, 2017, 12:05 AM by Beck Lockwood   [ updated Jul 21, 2017, 2:12 AM ]

A changing regulatory landscape for IVDs

Significant changes to European regulations for in vitro diagnostics (IVDs) have now been published and are due to be introduced over the next five years. 

The transition period allows manufacturers time to update technical documentation and processes to meet the new requirements. However, they will now find themselves subject to greater scrutiny of documentation, clinical evaluation, post-market clinical performance reviews, and traceability of devices through the supply chain.  

The implications of these changes were explored at a workshop, organised by the MHRA and MRC, which was held at the Academy of Medical Sciences, London, in May. Dr Michael Messenger, Deputy Director NIHR DEC Leeds, was invited to present a series of case studies, demonstrating methodological approaches to complying with some of the regulatory requirements.

“The DECs were set up to accelerate adoption of new IVDs into health and care systems and we welcome the increased clarity and rigour that these new regulations will bring,” says Dr Messenger.

“We will be monitoring new developments closely and we’re looking forward to continuing to work with our partners within these regulations to deliver new diagnostic tests which are both accurate and cost effective – and can deliver real benefits to patients.”

The NIHR DEC Leeds is keen to support the UK diagnostic industry through this regulatory transition period, by offering help with regulatory studies of scientific validity, analytical performance and clinical performance.  For further information please contact us.

21 July 2017

posted Jul 20, 2017, 11:49 PM by Beck Lockwood   [ updated Jul 21, 2017, 2:14 AM ]

NIHR DEC Leeds at ACB FOCUS 2017

The Association for Clinical Biochemistry (ACB) FOCUS 2017 National Meeting was held in the Royal Armouries, Leeds. The conference included key note presentations on ‘Metabolic and Molecular Bases for Congenital Hyperinsulation’ by Professor Mike Bennett and ‘Autopsies Save Lives’ by Dr Suzy Lishman. 

“We had an excellent scientific programme at this year’s event, ranging from clinical translation of metabolomic profiling, laboratory medicine for transgender patients and research collaborations with the young scientists of the European Federation of Laboratory Medicine,” said Dr Carys Lippiatt, Vice Chair of the Focus 2017 Organising Committee. “200 posters were presented , leading to lively discussion at lunchtime poster ward rounds."

NIHR DEC Leeds presented two posters at the event. The first focussed on the Quality Assessment of Measurement Procedures (QAMPs)  framework, which sets out methods of reducing uncertainty in measurement procedures applied to diagnostic testing. Presented by Dr Gemma Jones, the poster offered a case study for applying the framework to publications examining use of the biomarker NGAL in diagnostic testing for Acute Kidney Injury.

The second poster, presented by Dr Mike Messenger, aimed to encourage the next generation of clinical biochemists and laboratory professionals to take part in research.

“By highlighting the wealth of research opportunities available through the National Institute for Health Research, we hope to inspire the clinical research leaders of the future,” said Dr Messenger.

21 July 2017

posted Jul 20, 2017, 11:44 PM by Beck Lockwood   [ updated Jul 21, 2017, 2:14 AM ]


Diagnostics in times of change
The 2017 UK Diagnostic Forum was held in Oxford and hosted by NIHR DEC Oxford. This year’s theme was “Diagnostics in times of change”

Helen Radford, NIHR DEC Leeds Operational & Scientific Manager and Beth Shinkins, NIHR DEC Leeds Methodological Lead attended the two-day event, which brought together representatives from industry, academia and the NHS. Several key note speakers presented material, including Doris Ann Williams from the British In-vitro Diagnostics Association (BIVDA) whose presentation, “What will leaving the EU mean for life science in the UK?” provided a unique insight and lively discussion.

Other key presentations included: “The use of diagnostics in addressing antimicrobial resistance” delivered by Fiona Carragher, Deputy Chief Scientific officer, NHS England and “New Models of Care” by Samantha Jones, Vanguard CEO. 

12 July 2017

posted Jul 12, 2017, 5:29 AM by Beck Lockwood   [ updated Jul 17, 2017, 4:14 AM ]

Briefing event for SBRI Healthcare’s latest competition

The Yorkshire & Humber Academic Health Science Network and SBRI Healthcare are inviting individuals and organisations to learn more about the upcoming SBRI Healthcare funding competition “Cancer: Screening, Earlier Diagnosis & Faster Diagnosis,” which will open for applications at the end of July.

This free event will take place on Wednesday 26 July at Horizon, 2 Brewery Wharf, Kendall Street, Leeds.

For more details on the event and information on how to register please click here.

27 June 2017

posted Jun 27, 2017, 7:12 AM by Beck Lockwood

The NIHR Diagnostic Evidence Co-operative (DEC) Oxford two day course on diagnostic test development, evaluation and regulation
Worcester College, Oxford

 Bookings are now open for the Diagnostic Evidence Workshop which will be held on 28-29 September 2016 at Worcester College, Oxford.

This course covers evidence-based approaches to device evaluation including health economics, statistics for diagnostics in medicine, regulatory approval and funding advice and is aimed at all professionals working on diagnostic tests including people working in industry, academia, funding and regulation.

For course details, fees and booking info please visit the DEC website: www.oxford.dec.nihr.ac.uk

If you have any questions please email dec@phc.ox.ac.uk          

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3 April 2017

posted Apr 3, 2017, 3:17 AM by Beck Lockwood   [ updated Jul 25, 2017, 10:46 PM ]

Poster competition win for AKI Diagnostics team

A poster outlining research by NIHR DEC Leeds to evaluate new tests for the diagnosis of acute kidney injury has won first prize at an international conference on molecular medicine.

The AKI Diagnostics project poster was presented at Molecular Med Tri-Con 2017 in San Francisco in February, a conference that brings together professionals from industry, healthcare and academia to focus on discovery, genomics, diagnostics and information technology.

NIHR DEC Leeds Health Economist, Alison Smith, who led the study, explains: “We identified which commercially available tests look the most promising, based on the existing research and then determined what further studies would be needed, to provide an evidence base on which the healthcare provider could make an informed decision.”

Mike Messenger, Deputy Director of NIHR DEC Leeds, added: “Researchers often focus their efforts around generating evidence on the diagnostic accuracy of a test.  This evaluation nicely shows how the uncertainty around many other factors, such as the incidence or prevalence of a disease, or the effectiveness of interventions, can have a big impact on the estimated cost-effectiveness of a test. 

"Identifying these factors early enables us to ensure that subsequent research efficiently targets the information that’s needed by the health and care system, so ultimately commissioners are able to decide more quickly on adoption of these technologies.”

A podcast interview with Dr Smith and Dr Messenger is available here.

3 April 2017

posted Apr 3, 2017, 3:15 AM by Beck Lockwood   [ updated Apr 3, 2017, 3:23 AM ]

Beacon for Outstanding Contribution to Healthcare Award

Congratulations to NIHR DEC Leeds Clinical Director, Professor Peter Selby, who received the Beacon for Outstanding Contribution to Healthcare Award at the Medilink Yorkshire & Humber Healthcare Business Awards 2017.

Professor Peter Selby has held programme grants from Cancer Research UK, the European Research Council, and NIHR in the area of biomarker and proteomics research, biotherapy and clinical and patient centred research for 25 years. He has authored more than 500 publications and held £50m in external funding.

Professor Selby is also the President of the Association of Cancer Physicians, an NIHR Senior Investigator, President of the European Cancer Concord and a member of Council and the Research Strategy Committee of Cancer Research UK.

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